Post Doctoral Associate

Development of novel ZFP-based gene therapy approaches for monogenic disorders.

The Wolfe laboratory will be filling a postdoctoral position to develop new gene therapy reagents for the treatment of monogenic disorders in collaboration with other laboratories within UMMS. These efforts will focus on the creation of novel Cys₂His₂ zinc finger protein-based therapeutics for delivery to affected cell types. This project will focus on:

1) The development of Cys₂His₂ zinc finger proteins (ZFPs) with novel DNA binding specificity to target specific (therapeutic) genomic loci.

2) The application of these ZFPs in cell culture and in vivo models of disease to abrogate disease-associated phenotypes.

These studies will expose the successful candidate to cutting-edge ZFP design and selection approaches, as well as in vitro and in vivo delivery approachs. The successful candidate will also learn cutting edge deep-sequencing approaches to monitor the genome-wide binding locations and impact of the ZFPs on the genome and transcriptome. The successful candidate will have the opportunity to participate in meetings/conferences associated with gene therapy, which will broaden their exposure to cutting edge research within the field. In addition, the successful candidate will learn to utilize CRISPR-Cas9 and CRISPR-Cas12a nuclease technologies that are being developed in the Wolfe laboratory. Candidates should have a Ph.D. in biology, biochemistry, chemistry or a related biomedical science. In addition, the potential candidate must have strong oral and written communication skills and be eager to present research results at national meetings. Prior experience with Cys₂His₂ zinc finger proteins, cell culture, and deep-sequencing technologies is advantageous, but not required.

Applicants should send a letter (via email) describing their current research activities and their interest in this position, a CV (including publications) and contact information for three references, including your Ph.D. advisor.

Address letters to Scot Wolfe (scot.wolfe@umassmed.edu).

University of Massachusetts Chan Medical School

Department of Molecular, Cell and Cancer Biology

364 Plantation Street, LRB Room 619

Worcester, MA 01605

Further details about the Wolfe laboratory and the positions that are available can be found at https://www.umassmed.edu/Wolfe-Lab/

https://profiles.umassmed.edu/display/133161

UMass Medical School is committed to being an equal opportunity and affirmative action employer and recognizes the power of a diverse community. We encourage applications from protected veterans, individuals with disabilities and those with varied experiences, perspectives and backgrounds to consider UMass Medical School as their employer of choice.